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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-715 Replaces 04-339 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-EGFR (Tyr1069) Antibody 产品信息 格式 Serum 应用 应用 Detect phospho-EGFR (Tyr1069) using this Anti-phospho-EGFR (Tyr1069) Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids ...QR(pY)SS..., in which pY corresponds to phospho-tyrosine at residue 1069 of human epidermal growth factor receptor (EGFR) 宿主 Rabbit 特异性 phospho-EGFR (Tyr1069). Tyr1069 corresponds to the position in the human (isoform a) and mouse precursor proteins. This corresponds to Tyr1044 (indicated as Tyr1045 in several publications) in the mature human and mouse protein, and to Tyr1068 in the rat and pig precursor protein. 品种反应性 Human Species Reactivity Note Predicted to cross react with bovine, canine, and porcine based on sequence homology 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_201284.1
- NM_005228.3
- NM_201282.1
- NM_201283.1
基因符号 - mENA
- EGFR
- ERBB1
- ERBB
修改 - Phosphorylation
纯化方法 Serum UniProt编号 - P00533
UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
SIZE: 1210 amino acids; 134277 Da
SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.产品使用声明 质量保证 Routinely evaluated by immunoblot on RIPA lysates from EGF-stimulated A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,MABF585,Anti-CD45.1 Antibody (mouse), APC, clone A20
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