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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5563 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-GABA A Receptor β3 Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. 应用 应用 This Anti-GABA A Receptor β3 Antibody is validated for use in IP, WB for the detection of GABA A Receptor β3. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000. The antibody reacts with the ~50-56 kD protein in rat brain membrane fractions.
Immunopreciptation: The antibody will immunoprecipitate 48% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 MBP fusion protein from the cytosolic loop of rat GABAA receptor beta3 subunit. 宿主 Rabbit 特异性 GABAA receptor beta3 subunit. The apparent molecular mass of 50-53kDa in rat brain membrane fractions. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_021912.3
- NM_000814.4
Entrez基因汇总 This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in this gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism. Alternatively spliced transcript variants encoding isoforms with distinct signal peptides have been described. 基因符号 - GABA
- GABRB3
- MGC9051
UniProt编号 - P28472
UniProt汇总 FUNCTION: SwissProt: P28472 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SIZE: 473 amino acids; 54116 Da
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P28472 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. 包装信息 数量 100 µL
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