merck millipore,默克密理愽
  • merck millipore,默克密理博,475859,Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem

  • merck millipore,默克密理博,475859,Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem

    产品名称：Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem
    产品型号：475859
    A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane.

    merck millipore,默克密理博,475859,Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475859,Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₀Cl₄N₂O219315-22-7
    描述
    概述 A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50 = 5.3 and 4.42 µM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5 µM 24 h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5 µM 24 h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin (Cat. No. 495455) at 5 µM is shown to completely offset the mitochondrial fusion effect by 5 µM M1 in Mfn1 knockout MEF. Comparing to mdivi-1 (Cat. No. 475856), M1 exerts its effect via promoting fusion rather than inhibiting fission or division.
    产品目录编号 475859
    品牌系列 Calbiochem®
    同义词 (E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
    参考
    参考 Wang, D., et al. 2012. Angew. Chem. Int. Ed. 51, 9302.
    产品信息
    CAS号 219315-22-7
    形式 Off-white solid
    Hill配方 C₁₄H₁₀Cl₄N₂O
    Molar Mass 364.1
    可逆 Y
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475859,Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem

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