merck millipore,默克密理愽
  • merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem

  • merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem

    产品名称：JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem
    产品型号：420201
    The JMJD2 Inhibitor, 5-carboxy-8HQ, also referenced under CAS 5852-78-8, controls the biological activity of JMJD2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>

    merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C10H7NO35852-78-8
    描述
    概述 A cell-permeable, 5-carboxy-8-hydroxyquinoline that acts as a 2-oxoglutarate competitive inhibitor of JMJD (IC50 = 200 nM against JMJD2E in a FDH coupled assay). It demonstrates higher selectivity than 2.4-PDCA against other 2-OG oxygenases (IC50 = 2.4 µM, 1.7 µM, 20.5 µM, and 14.3 µM for JMJD2E, JMJD2A, FIH, and PHD2, respectively, in a MALDI-TOF MS assay). Additionally, it is shown to inhibit H3K9me3 demethylation (IC50 = 86.5 µM) in JMJD2A-transfected HeLa cells in a cellular demethylase assay, dose-dependently.

    This probe is supplied in conjunction with the Structural Genomics Consortium (SGC).
    产品目录编号 420201
    品牌系列 Calbiochem®
    同义词 IOX1, 5-carboxy-8HQ, Histone Lysine Demethylase Inhibitor II, JHDM Inhibitor I
    参考
    参考 Hamada, S., et al. 2010. J. Med. Chem. 53, 5629.
    King, D.N.F., et al. 2010. PLoS One 5, e15535.
    产品信息
    CAS号 5852-78-8
    形式 Orange solid
    Hill配方 C10H7NO3
    化学配方 C10H7NO3
    Molar Mass 189.17
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,36-002,Anti-phospho-SGK Antibody
下一件merck millipore产品：merck millipore,默克密理博,ZTC18S008,ZipTip 微量层析柱，具有 0.6 µL C18 树脂


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