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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5970 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Dishevelled-1 Antibody Alternate Names - DSH Homolog 1
- DSH
- DVL1
背景信息 DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation. The protein acts as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 mutation is likely responsible for transformation in neuroblastomas, and the Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene, thus DVL1 maybe important in these diseases as well. 产品信息 格式 Affinity Purified 控制 - SK-N-SH (neuroblastoma) whole cell lysates
演示 Liquid in PBS, pH 7.4, containing 0.01M sodium azide. 应用 应用 Anti-Dishevelled-1 Antibody is an antibody against Dishevelled-1 for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:500 using ECL. The antibody reacts with a protein of ~85kDa. Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 557-571 of human dishevelled-1 protein. 宿主 Rabbit 特异性 Dishevelled-1 protein (dvl-1). By Western blot the antibody shows no cross reactivity with recombinant dishevelled -2 or dishevelled -3 protein Pre-adsorption of the antibody with the immunogen peptide completely abolishes its reactivity by Western blot against dishevelled -1 protein. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_182779.3
- NM_181870.1
- NM_004421.2
Entrez基因汇总 DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. 基因符号 - MGC54245
- DVL1
- Dishevelled-1
- DVL
UniProt编号 - O14640
UniProt汇总 FUNCTION: SwissProt: O14640 # May play a role in the signal transduction pathway mediated by multiple Wnt genes.
SIZE: 695 amino acids; 75187 Da
SUBUNIT: Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.
PTM: Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.
SIMILARITY: SwissProt: O14640 ## Belongs to the DSH family. & Contains 1 DEP domain. & Contains 1 DIX domain. & Contains 1 PDZ (DHR) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots (not less than 10 μL) for up to 6 months. Avoid repeated freeze/thaw cycles. The use of high quality antiserum-grade plastic or glass is recommended. 包装信息 数量 50 µL
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