- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 36-002 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-SGK Antibody 产品信息 格式 Serum 控制 - PDK activated SGK samples
演示 UnPurified whole rabbit antiSerum containing 30% glycerol and 0.035% sodium azide. 应用 应用 Anti-phospho-SGK Antibody is an antibody against phospho-SGK for use in WB. 主要应用 - Western Blotting
应用说明 Not recommended for use with cell lysates. 生物信息 免疫原品种 peptide corresponding to amino acids surrounding Ser255/Thr256 of human SGK1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes phospho-SGK. 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005627.2
Entrez基因汇总 This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition. 基因符号 - SGK1
- SGK
修改 - Phosphorylation
纯化方法 Unpurified UniProt编号 - O00141
UniProt汇总 FUNCTION: SwissProt: O00141 # Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.
SIZE: 431 amino acids; 48942 Da
SUBUNIT: Interacts with NEDD4 and NEDD4L.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation.
TISSUE SPECIFICITY: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung.
PTM: Regulated by phosphorylation. Phosphoinositide 3-kinase (PI3- kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1. & Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells.
SIMILARITY: SwissProt: O00141 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot detected phospho-SGK after phosphorylation of unactive SGK1 (Catalog # 14-332) with PDK1 (Catalog # 14-280) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,419700,Isopeptidase T, Rabbit
下一件merck millipore产品：merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem
相关产品
merck millipore,默克密理博,SF-2008,DST; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,108387,叁(羟甲)胺基甲烷
merck millipore,默克密理博,AB5970,Anti-Dishevelled-1 Antibody
merck millipore,默克密理博,419700,Isopeptidase T, Rabbit
merck millipore,默克密理博,420201,JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem
merck millipore,默克密理博,ZTC18S008,ZipTip 微量层析柱，具有 0.6 µL C18 树脂
merck millipore,默克密理博,2011-OP,OmniPur Sequencing Buffer
merck millipore,默克密理博,05-781R,Anti-p70 S6 Kinase Antibody, clone 20-10C-6, rabbit monoclonal
