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merck millipore,默克密理博,420150,JNK Inhibitor XVI, JNK-IN-8 - Calbiochem
产品名称：JNK Inhibitor XVI, JNK-IN-8 - Calbiochem
产品型号：420150
The JNK Inhibitor XVI, JNK-IN-8 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,420150,JNK Inhibitor XVI, JNK-IN-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₉H₂₉N₇O₂ 描述 概述 A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50 = 4.67 nM, 18.7 nM, 980 pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50 = 486 nM in HeLa cells; 338 nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50 = 92 nM for V559D and 56 nM for T670I) and RIOK2 (120 nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. 产品目录编号 420150 品牌系列 Calbiochem®
同义词 (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide 参考 参考 Zhang, T., et al. 2011. Chem. Biol. 19, 140 产品信息 声明 Licensed under pending patent from Dana-Farber Cancer Institute. 形式 Light beige powder Hill配方 C₂₉H₂₉N₇O₂ 化学配方 C₂₉H₂₉N₇O₂ Molar Mass 507.6 可逆 N 结构配方图像 生物信息 主靶 JNK1, JNK2, JNK3 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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