merck millipore,默克密理博,492042,Nrf2 Activator III, TAT-14 Peptide

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Merck Millipore 默克密理愽

merck millipore,默克密理博,492042,Nrf2 Activator III, TAT-14 Peptide - Calbiochem

经验配方
C₁₃₇H₂₃₀N₄₈O₃₉

描述
概述	A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).
产品目录编号	492042
品牌系列	Calbiochem®
同义词	H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

参考
参考	Steel, R., et al. 2012. ACS Med Chem Lett. 3, 407.

产品信息
形式	White powder
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₁₃₇H₂₃₀N₄₈O₃₉
化学配方	C₁₃₇H₂₃₀N₄₈O₃₉
Molar Mass	3173.6
吸湿	Hygroscopic
肽序列	H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO
肽序列	H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,492042,Nrf2 Activator III, TAT-14 Peptide - Calbiochem

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