merck millipore,默克密理愽
  • merck millipore,默克密理博,14-558,PI3 Kinase (p120γ), 20 µg

  • merck millipore,默克密理博,14-558,PI3 Kinase (p120γ), 20 µg

    产品名称：PI3 Kinase (p120γ), 20 µg
    产品型号：14-558
    For use in Kinase Assays.

    merck millipore,默克密理博,14-558,PI3 Kinase (p120γ), 20 µg

  • 产品介绍
  • merck millipore,默克密理博,14-558,PI3 Kinase (p120γ), 20 µg

    描述
    产品目录编号 14-558
    品牌系列 Upstate
    商名
    • Upstate
    描述 PI3 Kinase (p120γ), 20 µg
    概述 N-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ).
    应用
    应用 For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002649.2
    Entrez基因汇总 This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
    基因符号
    • p120-PI3K
    • PIK3CG
    • p110-gamma
    • PI3-kinase
    • PIK3
    • PI3K
    • PI3Kgamma
    • PTDINS-3-kinase
    • PI3CG
    蛋白靶 PI3Kγ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 PI3K/PI4K
    UniProt编号
    • P48736
    UniProt汇总 FUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
    SIZE: 1102 amino acids; 126454 Da
    SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
    TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
    SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
    产品使用声明
    质量保证 Routinely evaluated in the PIProfiler.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 20 µg
    包装 Also available in 250μg size as catalog # 14-558M - Call for pricing and availability.

    merck millipore,默克密理博,14-558,PI3 Kinase (p120γ), 20 µg

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