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merck millipore,默克密理博,MAB447,Anti-ER-alpha Antibody, clone AER314
产品名称：Anti-ER-alpha Antibody, clone AER314
产品型号：MAB447
Use Anti-ER-alpha Antibody, clone AER314 (Mouse Monoclonal Antibody) validated in IP, WB, IHC(P) to detect Estrogen Receptor α also known as ER, ER1, Estradiol Receptor, ER-alpha.
merck millipore,默克密理博,MAB447,Anti-ER-alpha Antibody, clone AER314
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, B, H, M, R WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB447 Replaces 04-227 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-ER-alpha Antibody, clone AER314 Alternate Names - ER-alpha
- ER
- ER1
- Estradiol Receptor
产品信息 格式 Ascites 演示 Liquid 应用 应用 Use Anti-ER-alpha Antibody, clone AER314 (Mouse Monoclonal Antibody) validated in IP, WB, IHC(P) to detect Estrogen Receptor α also known as ER, ER1, Estradiol Receptor, ER-alpha. 主要应用 - Western Blotting
应用说明 Western blot (human)
Immunoprecipitation (human)
Immunohistochemistry (mouse): faint staining
Immunohistochemistry (human): reactive on paraffin embedded sections after microwaving. *Some cytoplasmic staining may be seen.
Final working dilutions must be determined by end user.生物信息 免疫原品种 Bovine estrogen receptor. 表位 a.a. 120-170 of hER-1 alpha 克隆 AER314 宿主 Mouse 特异性 Estrogen receptor 67kD hormone binding subunit. Epitope localized between aa 120-170.
AFFINITY:
0.8 nM同种型 IgG1 品种反应性 RabbitBovineHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000125.2
Entrez基因汇总 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. 基因符号 - DKFZp686N23123
- ESR1
- ER-alpha
- ESR
- Era
- ER
- NR3A1
- ESRA
UniProt编号 - P03372
UniProt汇总 FUNCTION: SwissProt: P03372 # Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
SIZE: 595 amino acids; 66216 Da
SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: SwissProt: P03372 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze-thaw cycles. 包装信息 数量 100 µL
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