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merck millipore,默克密理博,382115,Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem
产品名称：Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem
产品型号：382115
The Histone Acetyl Transferase Inhibitor VII, CTK7A controls the biological activity of Histone Acetyl Transferase. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,382115,Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₈H₂₃N₂NaO₆ 描述 概述 A cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC50 ≤ 25 and 50 µM, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC50 > 100 µM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100 µM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100 mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC50 of 0.93 µM and binds to Ca2+/calmodulin with high-affinity (Kd = 8.11 µM) and antagonize its functions in HCT15 cells. 产品目录编号 382115 品牌系列 Calbiochem®
同义词 Sodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic acid, Na salt, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III 参考 参考 Arif, M., et al. 2010. Chem. Biol. 17, 903.
Shim, J.S., et al. 2004. Chem. Biol. 11, 1455.
Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.产品信息 形式 Tan powder Hill配方 C₂₈H₂₃N₂NaO₆ 化学配方 C₂₈H₂₃N₂NaO₆ Molar Mass 506.5 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,203695,bpV(phen) - CAS 42494-73-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MABN721,Anti-PTK7 Antibody, clone 4F9
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