merck millipore,默克密理愽
  • merck millipore,默克密理博,373385,Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

  • merck millipore,默克密理博,373385,Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

    产品名称：Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem
    产品型号：373385
    The Hh Signaling Antagonist VII, JK184, also referenced under CAS 315703-52-7, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applic More>>

    merck millipore,默克密理博,373385,Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373385,Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₈N₄OS315703-52-7
    描述
    概述 A cell-permeable imidazopyridine compound that acts as downstream Hedgehog (Hh) pathway blocker by directly targeting the enzymatic activity of Adh7 (IC50 = 210 nM), the class IV alcohol dehydrogenase. Inhibits Hg-Ag-induced Gli-transcription activity (IC50 = 30 nM) as well as Gli1 and Ptc1 mRNA expression in a dose-dependent manner in H3H10T1/2 cells. Shown to exhibit ≥100-fold greater cytotoxicity towards five Hh activated tumor cells (GI50 ≤21 nM vs. 1.6 µM for the non-Hh activated H3H10T1/2 cells) in vitro and inhibit the growth of two xenografted tumors in mice (30-50% inhibition, 0.2 mg/mouse/day by p.o.) in vivo. Also acts as a microtubule-depolymerizing agent.
    产品目录编号 373385
    品牌系列 Calbiochem®
    同义词 N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
    参考
    参考 Cupido, T., et al. 2009. Angew Chem. 48, in press.
    Lee, J., et al. 2007. ChemBioChem. 8, 1916.
    产品信息
    CAS号 315703-52-7
    形式 Pink solid
    Hill配方 C₁₉H₁₈N₄OS
    化学配方 C₁₉H₁₈N₄OS
    Molar Mass 350.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373385,Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

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