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merck millipore,默克密理博,33-126,PIP5-Kinase HTRF Assay
产品名称：PIP5-Kinase HTRF Assay
产品型号：33-126
The PIP5 Kinase HTRF Assay kit provides a method for assaying PI(4)P-5 kinases in a homogenous 1920 well format. Suitable for screening of potential inhibitors of these enzymes.
merck millipore,默克密理博,33-126,PIP5-Kinase HTRF Assay
- 产品介绍
描述 产品目录编号 33-126 品牌系列 Upstate
商名 - Upstate
- HTRF
描述 PIP5-Kinase HTRF Assay 产品信息 部件 - Stop Reagent D
- Reaction Buffer (4X)
- DM A Detection Reagent
- DM C Detection Reagent
- DM E Detection Reagent
- Phosphatidylinositol 4-phosphate (1mM)
- Phosphatidylserine (1mM)
检测方法 HTRF 应用 应用 The PIP5 Kinase HTRF Assay kit provides a method for assaying PI(4)P-5 kinases in a homogenous 1920 well format. Suitable for screening of potential inhibitors of these enzymes. 主要应用 - Kinase Assay
生物信息 品种反应性 MouseHuman 可用的分析物 - PIP5 Kinase
Entrez基因编号 - NM_001195733.1
- NM_001135636.1
Entrez基因汇总 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.基因符号 - PIP5K1γ
- PIP5K1α
靶子系列 PI3K/PI4K 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 12 months at -70°C 包装信息 数量 1920 wells 包装 Kit capacity: 1920 wells
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