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merck millipore,默克密理博,MAB3662,Anti-TIF1 beta Antibody
产品名称：Anti-TIF1 beta Antibody
产品型号：MAB3662
Anti-TIF1 beta Antibody is a Mouse Monoclonal Antibody for detection of Transcriptional Intermediary Factor 1 also known as TIF1 beta & has been validated in ELISA, WB, ICC.
merck millipore,默克密理博,MAB3662,Anti-TIF1 beta Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ICC, ELISA M Ascites Monoclonal Antibody 描述 产品目录编号 MAB3662 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-TIF1 beta Antibody Alternate Names - TIF1beta
产品信息 格式 Ascites 演示 Ascites. Liquid. Contains no preservative. 应用 应用 Anti-TIF1 beta Antibody is a Mouse Monoclonal Antibody for detection of Transcriptional Intermediary Factor 1 also known as TIF1 beta & has been validated in ELISA, WB, ICC. 主要应用 - Western Blotting
- Immunocytochemistry
- ELISA
应用说明 Western blot: 1:500-1:5,000
Immunocytochemistry: 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Recombinant protein from mouse TIF1b. 宿主 Mouse 特异性 Recognizes transcriptional intermediary factor 1beta (TIF1beta). The epitope is localized between amino acids 123-834 of mouse TIF1beta. No cross reactivity with TIF1alpha. 同种型 IgG2b 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005762.2
Entrez基因汇总 The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. 基因符号 - KAP1
- TRIM28
- FLJ29029
- TIF1B
- RNF96
- TF1B
- KAP-1
- KRIP-1
- TIF1-beta
UniProt编号 - Q13263
UniProt汇总 FUNCTION: SwissProt: Q13263 # Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene (By similarity).
SIZE: 835 amino acids; 88550 Da
SUBUNIT: Associated with HP1 alpha (CBX5), beta (CBX1) and gamma (CBX3) in interphase nuclei (By similarity). Interacts with NCOR1 and CHD3. Interacts with SETDB1, ZFP53 and ZFP68. Interacts with CEBPB and NR3C1 (By similarity). Interacts directly with CBX5 via the PxVxL motif.
SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity).
DOMAIN: SwissProt: Q13263 The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity (By similarity). & Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the TRIM/RBCC family. & Contains 2 B box-type zinc fingers. & Contains 1 bromo domain. & Contains 1 PHD-type zinc finger. & Contains 1 RING-type zinc finger.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,529567,Potassium Phosphate, Dibasic, Trihydrate, Molecular Biology Grade - CAS 16788-57-1 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABS611,Anti-ABCB10 Antibody
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