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merck millipore,默克密理博,MABD20,Anti-PAX7 Antibody, clone 2F12H4
产品名称：Anti-PAX7 Antibody, clone 2F12H4
产品型号：MABD20
Anti-PAX7 Antibody, clone 2F12H4 is a Rat monoclonal antibody for detection of PAX7 also known as paired box homeotic gene 7, paired box protein Pax-7, paired domain gene 7 & has been validated in WB, More>>
merck millipore,默克密理博,MABD20,Anti-PAX7 Antibody, clone 2F12H4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M ChIP, WB, ICC R Purified Monoclonal Antibody 描述 产品目录编号 MABD20 描述 Anti-PAX7 Antibody, clone 2F12H4 Alternate Names - paired domain gene 7
- paired box 7
- PAX7 transcriptional factor
- paired box gene 7
- paired box homeotic gene 7
- paired box protein Pax-7
背景信息 Paired box protein Pax-7 (PAX7) belongs to the Pax family of transcription factors, a highly conserved group of proteins with crucial roles in tissue homeostasis and organogenesis. PAX7 is involved in the specification, survival, maintenance, and self-renewal of skeletal muscle progenitors and myogenic progenitors. It is primarily expressed in newly activated and quiescent satellite cells. Studies have shown that on activation, quiescent satellite cells co-express MyoD with PAX7 prior to proliferation, after which one or the other transcription factor is downregulated. Downregulation of MyoD instead of PAX7 leads to withdrawal from the cell cycle and myogenic differentiation, causing the cell to return to seemingly quiescent state. Chromosomal aberrations relating to PAX7 have been linked to rhabdomysarcoma 2 (RMS2). 产品信息 格式 Purified 控制 - Mouse fetal brain tissue lysate
演示 Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PAX7 Antibody, clone 2F12H4 is a Rat monoclonal antibody for detection of PAX7 also known as paired box homeotic gene 7, paired box protein Pax-7, paired domain gene 7 & has been validated in WB, ICC. 主要应用 - Chromatin Immunoprecipitation (ChIP)
- Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry: A previous lot of this antibody was shown to detect Pax7 localized in euchromatin of human Ewing’s
sarcoma cells. The antibodies are detected with Alexa Fluor® 488-conjugated anti-rat IgG. Each sample is counterstained with hoechst (Harada, A., et al. (2009). Hybridoma, 26:6. Hyb.2009.0039).生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse PAX7. 克隆 2F12H4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG2bκ 品种反应性 HumanMouse Species Reactivity Note Demonstrated to react with mouse. Shown to react with human by an independent laboratory (Harada, A., et al. (2009). Hybridoma, 26:6. Hyb.2009.0039). 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_035169
基因符号 - HuP1
- PAX7
- HUP1
- RMS2
- PAX7B
- Hup1
纯化方法 Protein G Purified UniProt编号 - P47239
UniProt汇总 FUNCTION: Probable transcription factor. May have a role in myogenesis.
SUBUNIT STRUCTURE: Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX (By similarity).
SUBCELLULAR LOCATION: Nucleus.
DEVELOPMENTAL STAGE: Expressed specifically during the development of the nervous and muscular system.
SEQUENCE SIMILARITIES: Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
Contains 1 paired domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse fetal brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected PAX7 in 10 µg of mouse fetal brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,33-126,PIP5-Kinase HTRF Assay
下一件merck millipore产品：merck millipore,默克密理博,529567,Potassium Phosphate, Dibasic, Trihydrate, Molecular Biology Grade - CAS 16788-57-1 - Calbiochem
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