merck millipore,默克密理愽
  • merck millipore,默克密理博,328006,ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

  • merck millipore,默克密理博,328006,ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

    产品名称：ERK Inhibitor - CAS 1049738-54-6 - Calbiochem
    产品型号：328006
    The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications More>>

    merck millipore,默克密理博,328006,ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,328006,ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₆N₂O₃S • HCl1049738-54-6
    描述
    概述 A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
    产品目录编号 328006
    品牌系列 Calbiochem®
    同义词 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
    参考
    参考 Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
    产品信息
    CAS号 1049738-54-6
    具有ATP竞争性 N
    形式 Light yellow solid
    Hill配方 C₁₄H₁₆N₂O₃S • HCl
    化学配方 C₁₄H₁₆N₂O₃S • HCl
    Molar Mass 328.8
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 ERK
    主靶IC50 ≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,328006,ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

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