merck millipore,默克密理愽
  • merck millipore,默克密理博,12-408,Histone H2B Peptide, biotin conjugate, residues 21-41

  • merck millipore,默克密理博,12-408,Histone H2B Peptide, biotin conjugate, residues 21-41

    产品名称：Histone H2B Peptide, biotin conjugate, residues 21-41
    产品型号：12-408
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes.

    merck millipore,默克密理博,12-408,Histone H2B Peptide, biotin conjugate, residues 21-41

  • 产品介绍
  • merck millipore,默克密理博,12-408,Histone H2B Peptide, biotin conjugate, residues 21-41

    重要规格表

    主要应用 Entrez基因编号 Uni Prot编号
    APA, IPNM_175055.2Q8N257
    描述
    产品目录编号 12-408
    品牌系列 Upstate
    商名
    • Upstate
    描述 Histone H2B Peptide, biotin conjugate, residues 21-41
    产品信息
    演示 Lyophilized powder
    应用
    应用 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes.
    主要应用
    • Affinity Precipitation Assay
    • Immunoprecipitation
    生物信息
    Entrez基因编号
    • NM_175055.2
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.
    基因符号
    • HIST3H2BB
    UniProt编号
    • Q8N257
    UniProt汇总 FUNCTION: SwissProt: Q8N257 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    SIZE: 126 amino acids; 13908 Da
    SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. & Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.
    SIMILARITY: SwissProt: Q8N257 ## Belongs to the histone H2B family.
    产品使用声明
    质量保证 Routinely evaluated as a substrate for histone-modifying enzymes.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,12-408,Histone H2B Peptide, biotin conjugate, residues 21-41

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