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经验配方 C₂₀H₂₂N₄ • HCl 描述 概述 A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo. 产品目录编号 317700 品牌系列 Calbiochem®
同义词 (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI 参考 参考 Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962. 产品信息 形式 Yellow powder 配方 Supplied as a hydrochloride salt. Hill配方 C₂₀H₂₂N₄ • HCl 化学配方 C₂₀H₂₂N₄ • HCl Molar Mass 354.9 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 H₂O or DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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