merck millipore,默克密理愽
  • merck millipore,默克密理博,189497,Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

  • merck millipore,默克密理博,189497,Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

    产品名称：Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem
    产品型号：189497
    A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

    merck millipore,默克密理博,189497,Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,189497,Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₃N₃S315702-99-9
    描述
    概述 A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
    产品目录编号 189497
    品牌系列 Calbiochem®
    同义词 N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
    参考
    参考 Turcotte, S., et al. 2008. Cancer Cell 14, 90.
    产品信息
    CAS号 315702-99-9
    形式 Beige solid
    Hill配方 C₁₅H₁₃N₃S
    化学配方 C₁₅H₁₃N₃S
    Molar Mass 267.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 22-41

    Harmful if swallowed.
    Risk of serious damage to eyes.
    S相 S: 26-39

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear eye/face protection.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Toxic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,189497,Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

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