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merck millipore,默克密理博,AB5675,Anti-Metabotropic Glutamate Receptor 5 Antibody, pain
产品名称：Anti-Metabotropic Glutamate Receptor 5 Antibody, pain
产品型号：AB5675
Anti-Metabotropic Glutamate Receptor 5 Antibody, pain is an antibody against Metabotropic Glutamate Receptor 5 for use in IH & WB.
merck millipore,默克密理博,AB5675,Anti-Metabotropic Glutamate Receptor 5 Antibody, pain
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5675 Replaces AB1596; 06-451 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Metabotropic Glutamate Receptor 5 Antibody, pain Alternate Names - mGluR5
产品信息 格式 Affinity Purified 控制 - Brain tissue
演示 Affinity Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.2 M NaCl, pH 7.6, containing 0.1 % sodium azide. 应用 应用 Anti-Metabotropic Glutamate Receptor 5 Antibody, pain is an antibody against Metabotropic Glutamate Receptor 5 for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot: 0.1-0.5 μg/mL using ECL on rat brain microsomal preparation. Reacts with a band of ~132 kDa. Immunohistochemistry: 0.1-0.2 μg/mL on rat brain and mouse brain sections fixed with 4% paraformaldehyde containing 15% saturated picric acid in 0.1M PB, pH 7.4.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from rat mGluR5. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes mGluR5. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000842.1
Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. 基因符号 - MGLUR5
- MGLUR5B
- GPRC1E
- GRM5
- mGluR5
- MGLUR5A
- mGlu5
纯化方法 Immunoaffinity purified UniProt编号 - P31424
UniProt汇总 FUNCTION: SwissProt: P41594 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current.
SIZE: 1212 amino acids; 132469 Da
SUBUNIT: The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P41594 ## Belongs to the G-protein coupled receptor 3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain material at 2–8°C for up to 6 months after date of receipt. 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,126658,Albumin, Human Serum, Fraction V, High Purity
下一件merck millipore产品：merck millipore,默克密理博,14-757,Abl (M351T) Protein, active, 10 µg
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