merck millipore,默克密理愽
  • merck millipore,默克密理博,553326,Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 - Calbiochem

  • merck millipore,默克密理博,553326,Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 - Calbiochem

    产品名称：Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 - Calbiochem
    产品型号：553326
    The Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 controls the biological activity of Rab7. This small molecule/inhibitor is primarily used for Membrane applications.

    merck millipore,默克密理博,553326,Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553326,Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₈N₂O₄S₂
    描述
    概述 A thiourea-derived small molecule that acts as a competitive inhibitor of nucleotide (BODIPY-GTP and BODIPY-GDP) binding by Rab7 (Ki = 12.89-19.70 nM). Equilibrates rapidly with Rab7 without affecting the rate of release of bound BODIPY-GTP or BODIPY-GDP. However, it exhibits a slightly lower potency against BODIPY-GDP bound Rab7 than BODIPY-GTP bound Rab7A. Acts by binding to the nucleotide binding pocket of Rab7. Also shown to inhibit nucleotide binding by mutant forms of Rab7 (Rab7Q67L and Rab7T22N) that are constitutively in the GTP and GDP bound states, with good potency. Also shown to block the nucleotide binding of several other Ras-related GTPases, but with reduced potency.
    产品目录编号 553326
    品牌系列 Calbiochem®
    同义词 2-(benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid, CID1067700, Cdc42 GTPase Inhibitor I, Rab2 GTPase Inhibitor, Rab GTPase Inhibitor, CDC42 Inhibitor I, Rab7 GTPase Inhibitor, Rac1 GTPase Inhibitor, Rac1 Inhibitor IV, Ras GTPase Inhibitor
    参考
    参考 Agola, J. O., et al. 2012. ACS Chem Bio. 7, 1095.
    产品信息
    形式 Beige powder
    Hill配方 C₁₈H₁₈N₂O₄S₂
    Molar Mass 390.48
    可逆 Y
    结构配方图像
    生物信息
    主靶 Rab7
    主靶Ki 12.89-19.70 nM
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553326,Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 - Calbiochem

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