merck millipore,默克密理博,371715,Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,371715,Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem
产品名称：Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem
产品型号：371715
An immunosuppressive secondary metabolite produced by several pathogenic fungi.

merck millipore,默克密理博,371715,Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem

产品介绍

merck millipore,默克密理博,371715,Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem

重要规格表

经验配方	CAS号
C₁₃H₁₄N₂O₄S₂	67-99-2

描述
概述	An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes. Farnesyltransferase (FTase) inhibitor (IC₅₀ = 1.1 µM). Reported to increase ryanodine Ca²⁺ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor. Specifically inhibits NF-κB activation in B and T cells at nanomolar concentrations.
产品目录编号	371715
品牌系列	Calbiochem®
同义词	2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a,10a-epidithio-pyrazinol[1,2α]indole-1,4-dione

参考
参考	Green, D., et al. 2000. J. Membr. Biol. 175, 223. Sutton, P., et al. 1995. Transplantation 60, 900. Waring, P., et al. 1995. Biochem. Pharmacol. 49, 1195. Waring, P., and Sjaarda, A. 1995. Int. J. Immunopharmacol. 17, 403. Van der Pyl, D., et al. 1992. J. Antibiot. 45, 1802. Jones, R.J., and Hancock, J.G. 1988. J. Gen. Microbiol. 134, 2067. Waring, P., et al. 1988. J. Biol. Chem. 263, 18493.

参考

Green, D., et al. 2000. J. Membr. Biol. 175, 223.
Sutton, P., et al. 1995. Transplantation 60, 900.
Waring, P., et al. 1995. Biochem. Pharmacol. 49, 1195.
Waring, P., and Sjaarda, A. 1995. Int. J. Immunopharmacol. 17, 403.
Van der Pyl, D., et al. 1992. J. Antibiot. 45, 1802.
Jones, R.J., and Hancock, J.G. 1988. J. Gen. Microbiol. 134, 2067.
Waring, P., et al. 1988. J. Biol. Chem. 263, 18493.

产品信息
CAS号	67-99-2
具有ATP竞争性	N
形式	White solid
Hill配方	C₁₃H₁₄N₂O₄S₂
化学配方	C₁₃H₁₄N₂O₄S₂
Molar Mass	326.4
可逆	N
结构配方图像

生物信息
主靶	FTase
主靶IC₅₀	1.1 µM against Farnesyltransferase (FTase)
纯度	≥98% by TLC

理化信息
细胞可渗透	N
溶解度	DMSO or EtOH

GHS安全信息
RTECS	KB4725000

安全信息
R相	R: 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
S相	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.