merck millipore,默克密理愽
  • merck millipore,默克密理博,444170,Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

  • merck millipore,默克密理博,444170,Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

    产品名称：Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem
    产品型号：444170
    An antibiotic with antitumor properties.

    merck millipore,默克密理博,444170,Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444170,Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₁H₃₈N₂O₇52665-74-4
    描述
    概述 An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
    产品目录编号 444170
    品牌系列 Calbiochem®
    参考
    参考 Kainuma, O., et al. 1997. Pancreas 15, 379.
    Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
    Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
    Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
    Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.
    产品信息
    CAS号 52665-74-4
    具有ATP竞争性 N
    形式 Yellow to brown solid
    Hill配方 C₃₁H₃₈N₂O₇
    化学配方 C₃₁H₃₈N₂O₇
    Molar Mass 550.7
    可逆 N
    结构配方图像
    生物信息
    主靶 Farnesyltransferase (FTAse)
    主靶IC50 5 µM against farnesyltransferase (FTase); 180 µM against geranylgeranyltransferase I (GGTase I)
    纯度 ≥96% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, MeOH or CHCl₃
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C).

    merck millipore,默克密理博,444170,Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

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