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merck millipore,默克密理博,04-145,Anti-NOD2 Antibody, clone 2D9
产品名称：Anti-NOD2 Antibody, clone 2D9
产品型号：04-145
Anti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP.
merck millipore,默克密理博,04-145,Anti-NOD2 Antibody, clone 2D9
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 04-145 描述 Anti-NOD2 Antibody, clone 2D9 Alternate Names - nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
- Caspase recruitment domain-containing protein 15
- Inflammatory bowel disease protein 1
- NLR family, CARD domain containing 2
- NOD-like receptor C2
- caspase recruitment domain family, member 15
- caspase recruitment domain protein 15
- nucleotide-binding oligomerization domain 2
- nucleotide-binding oligomerization domain containing 2
背景信息 NOD2 (nucleotide-binding oligomerization domain containing 2), also known as the caspase recruitment domain family, member 15 (CARD15), is a member of the NOD-like Receptor (NLR) family of proteins and plays an important role in the immune system. It is an intracellular pattern recognition receptor and is linked to inflammatory diseases such as inflammatory bowel disease/Crohn's Disease and Blau syndrome. NOD2 has two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules. Recently it is has been found to interact with NLRC4 and bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response. 产品信息 格式 Purified 控制 - Hyperplastic colorectal carcinoma tissue
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 His-tagged recombinant protein corresponding to human NOD2. 表位 Unknown 克隆 2D9 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes NOD2. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Proven to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_071445
Entrez基因汇总 This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn's disease and Blau syndrome. [provided by RefSeq]. 基因符号 - PSORAS1
- NOD2
- ACUG
- BLAU
- CARD15
- CD
- CLR16.3
- IBD1
- NLRC2
- NOD2B
纯化方法 Protein G purfied UniProt编号 - Q9HC29
UniProt汇总 FUNCTION: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).
SUBUNIT STRUCTURE: Binds to RICK by CARD-CARD interaction.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Monocytes-specific.
INVOLVEMENT IN DISEASE: Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash.
Defects in NOD2 are a cause of susceptibility to Crohn's disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn's disease is commonly classified as autoimmune disease.
Defects in NOD2 are a cause of susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease.
Defects in NOD2 are the cause of early-onset sarcoidosis (EOS) [MIM:609464]. Sarcoidosis is a multiorganic inflammatory disease with unknown etiology, characterized by the histologic features of non-caseating epithelioid granulomas. In childhood, 2 distinct types of sarcoidosis have been described. Usually the disease is detected in older children by chest radiography and the clinical manifestations are characterized by a classical triad of lung, lymph node, and eye involvement, similar to those in adults. In contrast, early-onset sarcoidosis (EOS), which usually appears in those younger than 4 years of age, is quite rare and has a distinct triad of skin, joint, and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, EOS is progressive and in many cases causes severe complications, such as blindness, joint destruction, and visceral involvement.
SEQUENCE SIMLARITIES: Contains 2 CARD domains.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.产品使用声明 质量保证 Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected NOD2 in hyperplastic colorectal carcinoma tissue. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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