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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H WB Ch Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5934 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Sox1 Antibody Alternate Names - Transcription factor SOX-1
背景信息 Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling. SOX1, therefore, defines the dividing neural precursors of the embryonic central nervous system. 产品信息 格式 Affinity Purified 控制 - Mouse neuronal stem cell lysate
演示 Purified chicken IgY in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide 应用 应用 Detect Sox1 using this Anti-Sox1 Antibody. Validated for use in WB & IC. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human SOX1 near the N-terminus. 表位 Near N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Chicken 特异性 This antibody recognizes SOX1 near the N-terminus. 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with Mouse, Human, and Rat. Predicted to react with Rhesus Monkey based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005977
Entrez基因汇总 This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. 基因符号 - SOX1
纯化方法 Affinity purified UniProt编号 - O00570
UniProt汇总 FUNCTION: Transcriptional activator (By similarity).
SIZE: 387 amino acids; 38856 Da
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Mainly in the developing central nervous system.
SIMILARITY: Contains 1 HMG box DNA-binding domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse neuronal stem cell lysate.
Western Blot Analysis: 0.05 µg/mL of this antibody detected SOX1 on 10 µg of mouse neuronal stem cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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