merck millipore,默克密理愽
  • merck millipore,默克密理博,171259,AMPK Activator III, DHPO - Calbiochem

  • merck millipore,默克密理博,171259,AMPK Activator III, DHPO - Calbiochem

    产品名称：AMPK Activator III, DHPO - Calbiochem
    产品型号：171259
    The AMPK Activator III, DHPO modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,171259,AMPK Activator III, DHPO - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,171259,AMPK Activator III, DHPO - Calbiochem

    重要规格表

    经验配方
    C₁₃H₉NO₂
    描述
    概述 A cell-permeable AMPK activator (20 mg/kg/d i.p. for 21d) that has been shown to attenuate fasting blood glucose, improve glucose disposal, and correct dyslipidemia in genetic (leptin deficient, ob/ob) and dietary (high-fat-fed) mouse models of insulin resistance over controls. IP injections for 14 days increases skeletal muscle glucose uptake by > ~30% and ~70% compared to vehicle-treated lean and obese mice, respectively. Treatment with 100 µM of DHPO results in a small but significant AMPK (Thr172) phosphorylation, and a concentration dependent increase in glucose uptake with a 2-fold increase over controls, in cultured myotubes. Furthermore, 20 nM Compound C demonstrates a 58% and 41% inhibition of DHPO-stimulated glucose up-take at concentrations of 50 µM and 100 µM DHPO, respectively.
    产品目录编号 171259
    品牌系列 Calbiochem®
    同义词 1-oxo-2-(2H-pyrrolium-1-yl)-1H-inden-3-olate, AMPK Signaling Activator III
    参考
    参考 Kandadi, M.R., et al. 2009. Biochem. Pharmacol. 79, 623.
    产品信息
    形式 Orange solid
    Hill配方 C₁₃H₉NO₂
    化学配方 C₁₃H₉NO₂
    Molar Mass 211.22
    结构配方图像
    生物信息
    纯度 >95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Unstable in solution; reconstitute just prior to use.

    merck millipore,默克密理博,171259,AMPK Activator III, DHPO - Calbiochem

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