merck millipore,默克密理愽
  • merck millipore,默克密理博,262015,DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

  • merck millipore,默克密理博,262015,DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

    产品名称：DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem
    产品型号：262015
    The DNA Base Excision Repair Pathway Inhibitor, also referenced under CAS 6960-45-8, controls the biological activity of APE1 (human apurinic/apyrimidinic endonuclease.

    merck millipore,默克密理博,262015,DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,262015,DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₉H₆N₂O₄6960-45-8
    描述
    概述 A cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 = ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
    产品目录编号 262015
    品牌系列 Calbiochem®
    同义词 7-Nitroindole-2-carboxylic acid, CRT0044876
    参考
    参考 Madhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.
    产品信息
    CAS号 6960-45-8
    具有ATP竞争性 N
    形式 Tan solid
    Hill配方 C₉H₆N₂O₄
    化学配方 C₉H₆N₂O₄
    Molar Mass 206.2
    可逆 N
    结构配方图像
    生物信息
    主靶 APE 1
    主靶IC50 ~3 µM against APE1 (human apurinic/apyrimidinic endonuclease
    纯度 ≥95% by titration
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,262015,DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,676494,VEGF Inhibitor, Je-11 - Calbiochem


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