merck millipore,默克密理愽
  • merck millipore,默克密理博,219334,β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

  • merck millipore,默克密理博,219334,β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

    产品名称：β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem
    产品型号：219334
    The β-Catenin/Tcf Inhibitor V, BC21, also referenced under CAS 691005-38-6, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applicat More>>

    merck millipore,默克密理博,219334,β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219334,β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₂H₃₆Cl₂Cu₂N₂O₂691005-38-6
    描述
    概述 A cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
    产品目录编号 219334
    品牌系列 Calbiochem®
    同义词 Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
    参考
    参考 Tian, W., et al. 2012. Biochemistry 51, 724.
    Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
    Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
    产品信息
    CAS号 691005-38-6
    形式 Dark brown solid
    Hill配方 C₃₂H₃₆Cl₂Cu₂N₂O₂
    化学配方 C₃₂H₃₆Cl₂Cu₂N₂O₂
    Molar Mass 678.6
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219334,β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

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