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merck millipore,默克密理博,MAB16983X,Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor 488 conjugated
产品名称：Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor 488 conjugated
产品型号：MAB16983X
Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor 488 conjugated detects level of Integrin α4 & has been published & validated for use in FC & IF.
merck millipore,默克密理博,MAB16983X,Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor 488 conjugated
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Pm, H FC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB16983X 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor® 488 conjugated Alternate Names - CD49d
背景信息 The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. 产品信息 格式 AlexaFluor®488 演示 Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide. 应用 应用 Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor 488 conjugated detects level of Integrin α4 & has been published & validated for use in FC & IF. 主要应用 - Flow Cytometry
应用说明 Immunofluorescence: 2 μg/mL Flow cytometry Optimal working dilutions must be determined by the end user. 生物信息 免疫原品种 Human T lymphocytes 克隆 clone P1H4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody is reactive with integrin alpha4 from human and primate species. 同种型 IgG1 品种反应性 PrimateHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000632.3
Entrez基因汇总 This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable 基因符号 - MAC-1
- ITGAM
- MO1A
- CD11b
- CR3A
- MAC1A
- CD11B
- MGC117044
UniProt编号 - P11215
UniProt汇总 FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
SIZE: 1152 amino acids; 127179 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.
DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
储存和货运信息 存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µg
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