merck millipore,默克密理博,444939,MEK Inhibitor VII - CAS 305350-87-2

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merck millipore,默克密理博,444939,MEK Inhibitor VII - CAS 305350-87-2 - Calbiochem
产品名称：MEK Inhibitor VII - CAS 305350-87-2 - Calbiochem
产品型号：444939
The MEK1/2 Inhibitor, also referenced under CAS 305350-87-2, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica More>>

merck millipore,默克密理博,444939,MEK Inhibitor VII - CAS 305350-87-2 - Calbiochem

产品介绍

merck millipore,默克密理博,444939,MEK Inhibitor VII - CAS 305350-87-2 - Calbiochem

重要规格表

经验配方	CAS号
C₁₆H₁₂F₃N₃S	305350-87-2

描述
概述	A cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK1/2 (IC₅₀ = 180 nM and 220 nM, respectively). Shown to inhibit AP-1 activity (IC₅₀ = 2.03 µM). Inhibits ERK1, MKK3/p38, MKK4, JNK, and PKC activities at higher concentrations (IC₅₀ > 10 µM). Reported to offer neuroprotection against ischemic brain injury in mice by selectively blocking ERK1/2 activation. Also suppresses IL-1β expression. Displays enhanced aqueous solubility compared to U0126 (Cat. No. 662005). Uncompetitive with respect to ATP.
概述	Supplied as a mixture of Z- and E-isomers.
产品目录编号	444939
品牌系列	Calbiochem®
同义词	SL327, Z-& E-α-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile

参考
参考	Hetman, M., et al. 2002. J. Biol. Chem. 277, 49577. Ohno, M., et al. 2001. Nat. Neurosci. 4, 1238. Wang, H., et al. 2001. Biochem. Biophys. Res. Commun. 286, 869. Scherle, P.A., et al. 2000. J. Biol. Chem. 275, 37086. Valjent, E., et al. 2000. J. Neurosci. 20, 8701. Watabe, A.M., et al. 2000. J. Neurosci. 20, 5924. Atkins, C.M., et al. 1998. Nat. Neurosci. 1, 602.

参考

Hetman, M., et al. 2002. J. Biol. Chem. 277, 49577.
Ohno, M., et al. 2001. Nat. Neurosci. 4, 1238.
Wang, H., et al. 2001. Biochem. Biophys. Res. Commun. 286, 869.
Scherle, P.A., et al. 2000. J. Biol. Chem. 275, 37086.
Valjent, E., et al. 2000. J. Neurosci. 20, 8701.
Watabe, A.M., et al. 2000. J. Neurosci. 20, 5924.
Atkins, C.M., et al. 1998. Nat. Neurosci. 1, 602.

产品信息
CAS号	305350-87-2
具有ATP竞争性	N
形式	Off-white solid
Hill配方	C₁₆H₁₂F₃N₃S
化学配方	C₁₆H₁₂F₃N₃S
Molar Mass	335.4
可逆	N
结构配方图像

生物信息
主靶	MEK 1, MEK 2
主靶IC₅₀	180 nM and 220 nM against MEK1 and MEK2, respectively
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.