merck millipore,默克密理愽
  • merck millipore,默克密理博,525330,PFKFB3 Inhibitor, 3PO - Calbiochem

  • merck millipore,默克密理博,525330,PFKFB3 Inhibitor, 3PO - Calbiochem

    产品名称：PFKFB3 Inhibitor, 3PO - Calbiochem
    产品型号：525330
    The PFKFB3 Inhibitor, 3PO controls the biological activity of PFKFB3.

    merck millipore,默克密理博,525330,PFKFB3 Inhibitor, 3PO - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,525330,PFKFB3 Inhibitor, 3PO - Calbiochem

    重要规格表

    经验配方
    C₁₃H₁₀N₂O
    描述
    概述 A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~ 1.4 µM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70 mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2.
    产品目录编号 525330
    品牌系列 Calbiochem®
    同义词 (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO
    参考
    参考 Clem, B., et al. 2008. Mol. Cancer Ther. 7, 110.
    产品信息
    形式 Pale yellow solid
    Hill配方 C₁₃H₁₀N₂O
    化学配方 C₁₃H₁₀N₂O
    Molar Mass 210.2
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,525330,PFKFB3 Inhibitor, 3PO - Calbiochem

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