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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB3291 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-H-Ras Antibody, clone 7D7.2 产品信息 格式 Purified 演示 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, 0.1% sodium azide 应用 应用 This Anti-H-Ras Antibody, clone 7D7.2 is validated for use in ELISA, WB for the detection of H-Ras. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot
ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Full-length recombinant human H-Ras - GST fusion protein 克隆 7D7.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes H-Ras (the oncogene of Harvey murine sarcoma virus). Approximate molecular weight of 21 kDa. 同种型 IgG2b 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_176795.2
- NM_005343.2
基因符号 - HRAS1
- HRAS
- c-bas/has
- H-Ras-1
- RASH1
- Ha-Ras
- K-ras
- N-ras
- p21ras
- c-H-ras
- H-RasIDX
- CTLO
UniProt编号 - P01112
UniProt汇总 FUNCTION: SwissProt: P01112 # Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
SIZE: 189 amino acids; 21298 Da
SUBUNIT: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
DISEASE: SwissProt: P01112 # Defects in HRAS are the cause of Costello syndrome [MIM:218040]; also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. & Mutations which change positions 12, 13 or 61 activate the potential of c-ras to transform cultured cells and are implicated in a variety of human tumors. & Defects in HRAS are a cause of bladder cancer [MIM:109800]. & Defects in HRAS are also the cause of oral squamous cell carcinoma (OSCC).
SIMILARITY: SwissProt: P01112 ## Belongs to the small GTPase superfamily. Ras family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months.
WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water.包装信息 数量 100 µg
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