merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5380,Anti-Nitric Oxide Synthase I Antibody

  • merck millipore,默克密理博,AB5380,Anti-Nitric Oxide Synthase I Antibody

    产品名称：Anti-Nitric Oxide Synthase I Antibody
    产品型号：AB5380
    This Anti-Nitric Oxide Synthase I Antibody is validated for use in IH, WB for the detection of Nitric Oxide Synthase I.

    merck millipore,默克密理博,AB5380,Anti-Nitric Oxide Synthase I Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5380,Anti-Nitric Oxide Synthase I Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Sh, H, M, Mk, RWB, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5380
    Replaces AB1552
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nitric Oxide Synthase I Antibody
    Alternate Names
    • nNOS
    • NOS I
    • bNOS
    产品信息
    格式 Serum
    控制
    • Brain tissue
    演示 Rabbit Serum. Liquid containing 0.05% sodium azide.
    应用
    应用 This Anti-Nitric Oxide Synthase I Antibody is validated for use in IH, WB for the detection of Nitric Oxide Synthase I.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:1,000-1:3,000 (ECL).

    Immunohistochemistry: 1:1,000-1:2,000 (ABC).

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant human neuronal nitric oxide synthase.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Neuronal nitric oxide synthase (nNOS, NOS-I, bNOS). No cross reaction with iNOS and eNOS by immunohistochemistry.
    品种反应性 SheepHumanMouseMonkeyRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000620.1
    基因符号
    • EC 1.14.13.39
    • NOS1
    • bNOS
    • nNOS
    • NC-NOS
    • N-NOS
    • IHPS1
    • NOS
    纯化方法 Unpurified
    UniProt编号
    • P29475
    UniProt汇总 FUNCTION: SwissProt: P29475 # Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.
    COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
    SIZE: 1434 amino acids; 160970 Da
    SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity).
    SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
    TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
    DOMAIN: SwissProt: P29475 The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles (By similarity).
    DISEASE: SwissProt: P29475 # Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction.
    SIMILARITY: Belongs to the NOS family. & Contains 1 flavodoxin-like domain. & Contains 1 PDZ (DHR) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5380,Anti-Nitric Oxide Synthase I Antibody

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