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描述 概述 Native, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64 kDa (α), 64 kDa (β), and 22 kDa (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC). 产品目录编号 204896 品牌系列 Calbiochem®
参考 参考 Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997.
Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.产品信息 CAS号 80295-58-5 形式 Liquid 配方 In PBS, pH 7.2. Molar Mass 150000 生物信息 纯度 ≥85% by SDS-PAGE 来源 Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. 特异活性 ≥150,000 C₈H₅0 units/mg 浓缩标签 Please refer to vial label for lot-specific concentration
理化信息 污染物 IgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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