merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1564,Anti-Estrogen Receptor α Antibody, clone F3-A

  • merck millipore,默克密理博,04-1564,Anti-Estrogen Receptor α Antibody, clone F3-A

    产品名称：Anti-Estrogen Receptor α Antibody, clone F3-A
    产品型号：04-1564
    Anti-Estrogen Receptor α Antibody, clone F3-A is a mouse monoclonal antibody for detection of Estrogen Receptor α also known as Estradiol receptor & Nuclear receptor subfamily 3 group A member 1 has b More>>

    merck millipore,默克密理博,04-1564,Anti-Estrogen Receptor α Antibody, clone F3-A

  • 产品介绍
  • merck millipore,默克密理博,04-1564,Anti-Estrogen Receptor α Antibody, clone F3-A

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 04-1564
    描述 Anti-Estrogen Receptor α Antibody, clone F3-A
    Alternate Names
    • estrogen receptor alpha delta 6,7 isoform
    • Estradiol receptor
    • Nuclear receptor subfamily 3 group A member 1
    • estrogen receptor 1
    • estrogen receptor alpha
    • estrogen receptor alpha delta 4*,5,6,7*/633 isoform
    背景信息 Estrogen Receptor α (ERα) is a 65 kDa nuclear hormone receptor. This steroid hormone receptor is involved in the regulation of eukaryotic gene expression and affects cellular proliferation and differentiation in target tissues. ERα is a ligand-activated transcription factor and upon being bound by a ligand such as estrogen, a conformational change occurs that allows dimerization and binding to an estrogen response element. When bound to DNA, Estrogen Receptor α can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Two ERs are known, ERα, classically known as ER, and ERβ. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα.
    产品信息
    格式 Ascites
    控制
    • Mouse ovary tissue lysate
    演示 Unpurified mouse monoclonal IgG1κ preservative-free ascites.
    应用
    应用 Anti-Estrogen Receptor α Antibody, clone F3-A is a mouse monoclonal antibody for detection of Estrogen Receptor α also known as Estradiol receptor & Nuclear receptor subfamily 3 group A member 1 has been validated in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Estrogen Receptor α in A431 cells.
    生物信息
    免疫原品种 Linear peptide corresponding to human Estrogen Receptor α.
    表位 Unknown
    克隆 clone F3-A
    宿主 Mouse
    特异性 This antibody recognizes Estrogen Receptor α.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000116
    Entrez基因汇总 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq].
    基因符号
    • NR3A1
    • ESR1
    • ER
    • ER-alpha
    • ESR
    • ESRA
    • Era
    纯化方法 Unpurified
    UniProt编号
    • P03372
    UniProt汇总 FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

    SIZE: 595 amino acids; 66216 Da

    SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.

    SUBCELLULAR LOCATION: Nucleus.

    DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.

    PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.

    SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.

    MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites. ...
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse ovary tissue lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected Estrogen Receptor α on 10 µg of mouse ovary tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1564,Anti-Estrogen Receptor α Antibody, clone F3-A

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