merck millipore,默克密理愽
  • merck millipore,默克密理博,118501,ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

  • merck millipore,默克密理博,118501,ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

    产品名称：ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem
    产品型号：118501
    The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephospho More>>

    merck millipore,默克密理博,118501,ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,118501,ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₁₈Cl₃FN₄O₃S905973-89-9
    描述
    概述 A cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway.
    产品目录编号 118501
    品牌系列 Calbiochem®
    同义词 CGK 733
    参考
    参考 Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
    Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
    Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
    Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
    产品信息
    CAS号 905973-89-9
    具有ATP竞争性 N
    形式 Pale yellow solid
    Hill配方 C₂₃H₁₈Cl₃FN₄O₃S
    化学配方 C₂₃H₁₈Cl₃FN₄O₃S
    Molar Mass 555.8
    可逆 N
    结构配方图像
    生物信息
    主靶 ATM/ATR
    主靶IC50 ~200 nM against ATM and ATR
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,118501,ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

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