merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE283,Anti-p53 Antibody, clone PAb421

  • merck millipore,默克密理博,MABE283,Anti-p53 Antibody, clone PAb421

    产品名称：Anti-p53 Antibody, clone PAb421
    产品型号：MABE283
    Use Anti-p53 Antibody, clone PAb421 (Mouse Monoclonal Antibody) validated in WB, IP, IHC to detect p53 also known as Cellular tumor antigen p53, Tumor suppressor p53.

    merck millipore,默克密理博,MABE283,Anti-p53 Antibody, clone PAb421

  • 产品介绍
  • merck millipore,默克密理博,MABE283,Anti-p53 Antibody, clone PAb421

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE283
    描述 Anti-p53 Antibody, clone PAb421
    Alternate Names
    • Tumor suppressor p53
    • Cellular tumor antigen p53
    背景信息 p53 was discovered in 1979 as a cellular protein associating with the transforming protein of SV40 tumor virus. Since then, many different biochemical functions have been attributed to the 53 kDa phosphoprotein. Experimental evidence has suggested that p53 acts as a negative regulator of cell growth in normal cells). Thus, the inactivation or mutation of p53 may be an essential step in the development of malignancy. Wild-type p53 levels in normal cells and tissues were found to be very low. Mutant p53 polypeptide, however, is often found to be present at high concentrations in mammalian tumors and tumor cell lines. For example, in an immuno-histochemistry study 40% of human breast cancer showed elevated levels of mutant p53 in the cell nucleus. Mutations of the p53 protein have some characteristic features: Most of them are missense point mutations giving rise to an altered protein function. Also, many, but not all, mutant p53 proteins exhibit a common mutant structure, which can be recognized by monoclonal antibodies specific for p53 in the mutant conformation.
    产品信息
    格式 Purified
    控制
    • Mouse brain tissue lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-p53 Antibody, clone PAb421 (Mouse Monoclonal Antibody) validated in WB, IP, IHC to detect p53 also known as Cellular tumor antigen p53, Tumor suppressor p53.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot from independent laboratory immunoprecipitated p53 in IP (Lehman, T. A., et al. (1991). Cancer Res. 51(15):4090-4096.; Harlow, E., et al. (1981). J Virol. 39(3):861-869.)

    Immunohistochemistry Analysis: A representative lot from an independent laboratory detected p53 in human breast cancer tissue (Davidoff, A. M., et al. (1992). Proc Natl Acad Sci USA. 89(8):3439-3442.).
    生物信息
    免疫原品种 Partially purified mouse p53
    表位 Amino acids 376-378 in human p53
    克隆 PAb421
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes amino acids 376-378 of human p53.
    同种型 IgG2aκ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with Mouse. Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001120705
    基因符号
    • Trp53
    • Tp53
    • P53
    纯化方法 Protein G purified
    UniProt编号
    • P02340
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse brain tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected p53 in 10 µg of mouse brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE283,Anti-p53 Antibody, clone PAb421

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