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经验配方 C₃₁H₄₀O₄ 描述 概述 The differentiation-inducer all-trans-Retinoic Acid (ATRA; Cat. No. 554720) and the histone deacetylase inhibitor (HDI) Butyric Acid (BA; Cat. No. 567430) are incorporated chemically via a benzyl ester linkage into a single more permeant mutual prodrug (MP) to facilitate their cellular uptake and to better synergize their cancer killing potency. The growth inhibitions of PC-3 and MDA-MB-231 by the MP (IC50 = 1.02 and 0.01 µM, respectively) are much superior to those achieved by separate (IC50 = 7.6 and 10.85 µM, respectively, with ATRA; IC50 = 72.44 and >1000 µM, respectively, with BA) or combined dosing of ATRA/BA (55% vs. 30% PC-3 growth inhibition by 10 µM MP vs. co-treatment of 10 µM each of ATRA & BA). At 37°C, VNLG/124 is completely converted to ATRA and BA within an hour in fresh murine plasma, but is otherwise stable for more than 24 hours in the absence of esterase activity in 20 mM PBS. 产品目录编号 554723 品牌系列 Calbiochem®
同义词 4-(Butanoyloxymethyl)phenyl-(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate, VNLG/124, HDAC Inhibitor XV 参考 参考 Gediya, L.K., et al. 2008. J. Med. Chem. 51, 3895. 产品信息 形式 Yellow solid Hill配方 C₃₁H₄₀O₄ 化学配方 C₃₁H₄₀O₄ Molar Mass 476.7 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 22-36/37/38-63
Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
Possible risk of harm to the unborn child.S相 S: 22-26-36-45
Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Harmful
储存 -20°C
避光 Protect from light
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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