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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABC232 Replaces MABC177; MABC176 描述 Anti-LC3 Antibody Alternate Names - Microtubule-associated protein 1 light chain 3 alpha
- Microtubule-associated proteins 1A/1B light chain 3A
- Autophagy-related protein LC3 A
- Autophagy-related ubiquitin-like modifier LC3 A
- MAP1 light chain 3-like protein 1
- MAP1A/MAP1B light chain 3 A
- MAP1A/MAP1B LC3 A
背景信息 LC3A is composed of a heavy chain and multiple light-chain subunits. The molecular machinery required for autophagy is highly conserved in all eukaryotes as seen by the high degree of conservation of proteins involved in the formation of the autophagosome membranes. Recently, both yeast Apg8p and its rat homologue LC3-II were identified as essential constituents of autophagosome membrane as a processed form. In addition, both the yeast and human proteins exist in two modified forms produced by a series of post-translational modifications including a critical C-terminal cleavage after a conserved Gly residue, and the smaller processed form is associated with the autophagosome membranes Results revealed different regulation of the three human isoforms of LC3-II and implicate that the three isoforms may have different physiological functions. Two forms of LC3A, called LC3-I and -II, were produced post-translationally in various cells. LC3-I is cytosolic, whereas LC3-II is membrane bound. 产品信息 格式 Serum 控制 - NIH/3T3 cell lysate
演示 Rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-LC3 Antibody is an antibody against LC3 for use in Western Blotting. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A 1;1,000 dilution from a representative lot detected LC3 in 10 µg of mouse embryonic fibroblast tissue lysate and MCF-7 cell lysate. 生物信息 免疫原品种 Linear peptide corresponding to human LC3. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_115903
基因符号 - MAP1LC3A
纯化方法 Unpurified UniProt编号 - Q9H492
产品使用声明 质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: A 1;1,000 dilution of this antibody detected LC3 in 10 µg of NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,6791,Vitamin B₁₂ - CAS 68-19-9 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,SLHV033RS,Millex-HV 过滤器，0.45 µm，PVDF，33 mm，可 γ 射线灭菌，已灭菌
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