merck millipore,默克密理愽
  • merck millipore,默克密理博,203661,Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem

  • merck millipore,默克密理博,203661,Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem

    产品名称：Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem
    产品型号：203661
    The Bruton's Tyrosine Kinase Inhibitor III, also referenced under CAS 936563-87-0, controls the biological activity of Bruton's Tyrosine Kinase.

    merck millipore,默克密理博,203661,Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,203661,Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₅H₂₄N₆O₂936563-87-0
    描述
    概述 A cell-permeable pyrrolopyridinyl-acryloyl compound that acts as a highly potent, selective, and irreversible inhibitor of BTK (IC50 = 720 pM), while affecting Lyn, Lck, and Itk activity only at much higher concentrations (IC50 = 14 nM, 97 nM, and 1.0 µM, respectively). Inhibits BTK-dependent PLC-γ1 phosphorylation and Ca2+ flux in human B cell line Ramos in vitro (IC50 = 14 nM and 40 nM, respectively) and is of excellent efficacy in a murine rheumatoid archritis model in vivo (>95% inhibition at 10 mg/kg/day, p.o.).
    产品目录编号 203661
    品牌系列 Calbiochem®
    同义词 1-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, N-Acryloyl-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine
    参考
    参考 Pan, Z., et al. 2007. ChemMedchem. 2, 58.
    产品信息
    CAS号 936563-87-0
    形式 White crystalline solid
    Hill配方 C₂₅H₂₄N₆O₂
    化学配方 C₂₅H₂₄N₆O₂
    Molar Mass 440.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,203661,Bruton's Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,345670,Galanthamine, Hydrobromide - CAS 69353-21-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,AB15620,Anti-Olig1 Antibody


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