merck millipore,默克密理愽
  • merck millipore,默克密理博,14-599M,IRAK4 Protein, active, 250 µg

  • merck millipore,默克密理博,14-599M,IRAK4 Protein, active, 250 µg

    产品名称：IRAK4 Protein, active, 250 µg
    产品型号：14-599M
    Active, N-terminal His6-tagged, recombinant full length, human IRAK4, for use in Kinase Assays.

    merck millipore,默克密理博,14-599M,IRAK4 Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-599M,IRAK4 Protein, active, 250 µg

    描述
    产品目录编号 14-599M
    品牌系列 Upstate
    商名
    • Upstate
    描述 IRAK4 Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant full length, human IRAK4
    应用
    应用 Active, N-terminal His6-tagged, recombinant full length, human IRAK4, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_016123.1
    Entrez基因汇总 Interleukin-1 receptor (see IL1R; MIM 147810)-associated kinases (e.g., IRAK1; MIM 300283) are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.[supplied by OMIM]
    基因符号
    • IPD1
    • IRAK4
    • NY-REN-64
    • REN64
    • IRAK-4
    • LOC51135
    蛋白靶 IRAK4
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TKL
    UniProt编号
    • Q9NWZ3
    UniProt汇总 FUNCTION: SwissProt: Q9NWZ3 # Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.
    COFACTOR: Magnesium.
    SIZE: 460 amino acids; 51530 Da
    SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
    DISEASE: SwissProt: Q9NWZ3 # Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. & Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
    SIMILARITY: SwissProt: Q9NWZ3 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of MBP (Catalog #13-104)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-599) and in bulk (cat# 14-599-K).

    merck millipore,默克密理博,14-599M,IRAK4 Protein, active, 250 µg

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