merck millipore,默克密理愽
  • merck millipore,默克密理博,444967,MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem

  • merck millipore,默克密理博,444967,MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem

    产品名称：MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem
    产品型号：444967
    The MEK1/2 Inhibitor IV, also referenced under CAS 212631-67-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>

    merck millipore,默克密理博,444967,MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444967,MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₃BrClF₂IN₂O₂212631-67-9
    描述
    概述 A cell-permeable, blood-brain barrier permeant, and orally active hydroxamate compound that is reported to inhibit MEK activity (IC50 = 10-100 nM) without competing against ATP or Erk binding and exhibit excellent selectivity over 27 other cellular kinases, including JNK, MAPK2/ERK2, SAPK2a, SAPK2b, SAPK3, and SAPK4 (IC50 > 10 µM). Shown to be superior to PD 98059 (Cat. Nos. 513000 and 513001) and U0126 (Cat. No. 662005) in suppressing Erk1/2 phosphorylation in Hep3B, HepG2, PLC, and SKHep human liver cancer cells (IC50 <0.1 µM) in vitro and effectively reduce Erk1/2 phosphorylation in hippocampal tissue in mice (ED50 <50 mg/kg, i.p.) in vivo. Both PD184161 and U0126 are shown to induce necrosis of several types of glucose-deprived cells via an indirect action on the F0 component of the mitochondrial F1F0-ATPase/synthase.
    产品目录编号 444967
    品牌系列 Calbiochem®
    同义词 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromo-benzamide, PD184161, MEK Inhibitor IV
    参考
    参考 Yip-Schneider, M.T., et al. 2009. J. Pharmacol. Exp. Ther. 329, 1063.
    Duman, C.H., et al. 2007. Biol. Psychiatry 61, 661.
    Klein, P.J., et al. 2006. Neoplasia 8, 1.
    Thottassery, J.V., et al. 2004. Cancer Res. 64, 4637.
    Yung, H.W., et al. 2004. Biochem. Pharmacol. 68, 351.
    产品信息
    CAS号 212631-67-9
    形式 White solid
    Hill配方 C₁₇H₁₃BrClF₂IN₂O₂
    化学配方 C₁₇H₁₃BrClF₂IN₂O₂
    Molar Mass 557.6
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444967,MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,345670,Galanthamine, Hydrobromide - CAS 69353-21-5 - Calbiochem


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