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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-157 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-FAK (Tyr576) Antibody 产品信息 格式 Serum 演示 antiserum with 0.05% sodium azide and 30% glycerol 应用 应用 This Anti-phospho-FAK (Tyr576) Antibody is validated for use in WB, IC for the detection of phospho-FAK (Tyr576). 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 571-582 of human FAK (MEDST[pY]YKASKG-C) 宿主 Rabbit 特异性 FAK phosphorylated at Tyr576 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005607 / NM_153831
Entrez基因汇总 This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. 基因符号 - FAK
- PTK2
- pp125FAK
- FADK
- FAK1
修改 - Phosphorylation
纯化方法 Antiserum UniProt编号 - Q05397
UniProt汇总 FUNCTION: SwissProt: Q05397 # Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
SIZE: 1052 amino acids; 119233 Da
SUBUNIT: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with SHB (By similarity). Interacts with TGFB1I1.
SUBCELLULAR LOCATION: Cell junction, focal adhesion; Cytoplasmic side. Note=Constituent of focal adhesions.
TISSUE SPECIFICITY: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.
DOMAIN: SwissProt: Q05397 The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL (By similarity). & The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions.
PTM: Phosphorylated on 6 tyrosine residues upon activation.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoprecipitating FAK using anti-FAK (06-543) from p60Src(527F)-transformed Rat-2 cells but not control Rat-2 cells; phospho-specificity was confirmed by dephosphorylation of the FAK protein with lambda-phosphatase 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,AB15620,Anti-Olig1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,07-483,Anti-UBB+1 Antibody, Ubi2a
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