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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-483 Replaces 04-454 品牌系列 Upstate
商名 - Upstate
描述 Anti-UBB+1 Antibody, Ubi2a 产品信息 格式 Purified 演示 0.05% sodium azide and 30% glycerol 应用 应用 This Anti-UBB+1 Antibody, Ubi2a is validated for use in WB, IH for the detection of UBB+1. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Thyroglobulin-conjugated, synthetic peptide corresponding to amino acids 85-95 of human UBB+1 宿主 Rabbit 特异性 UBB+1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因汇总 This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. 基因符号 - CEP80
- ubiquitin
- ubiquitin-CEP80
- UBCEP1
- Ubiquitin.
- UBA52
- UBCEP2
- UBA80
- UBC
- UBB
- HUBCEP80
- RPS27A
纯化方法 Antiserum UniProt编号 - P62988
UniProt汇总 FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
SIZE: 76 amino acids; 8565 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).产品使用声明 质量保证 routinely evaluated by immunoblot in bacterial lysates containing Histagged UBB+1 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,06-942,Anti-acetyl-Histone H3 (Lys9) Antibody
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