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merck millipore,默克密理博,178477,ApoE4 Modulator, PH002 - Calbiochem
产品名称：ApoE4 Modulator, PH002 - Calbiochem
产品型号：178477
A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells thereby revers More>>
merck millipore,默克密理博,178477,ApoE4 Modulator, PH002 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₇H₃₃N₅O₄ 描述 概述 A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells (IC50 = 116 nM) thereby reversing the detrimental effects of ApoE4. Established to be more potent than GIND25. Restores mitochondrial functions and elevates the levels of complex IV subunit 1. Shown to increase in COX1 levels in primary neurons from NSE-ApoE4 transgenic mouse cortex and hippocampus. Shown to rescue impairments of mitochondrial motility in primary neurons from NSE-ApoE4 transgenic mice (~ 200 nM). Also restores endoplasmic reticulum and Golgi apparatus transit of ApoE4 in cultured neurons and brings it to levels normally found in ApoE3 and ApoE4-R61T. 产品目录编号 178477 品牌系列 Calbiochem®
同义词 4-{4-[2-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-acetylamido]-benzyl}-piperazine-1-carboxylic acid tert-butyl ester, ApoE4 Structure Corrector, PH-002, Apolipoprotein E4 structure corrector 参考 参考 Chen, H., et al. 2011. J. Biol. Chem. 287, 5253.
Brodbeck, J., et al. 2011. J. Bio. Chem. 286, 17217.产品信息 形式 White powder Hill配方 C₂₇H₃₃N₅O₄ Molar Mass 491.58 可逆 Y 结构配方图像 生物信息 主靶 APOE4 主靶IC50 116 nM 纯度 ≥99% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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