merck millipore,默克密理愽
  • merck millipore,默克密理博,14-497M,PKC η Protein, active, 250 µg

  • merck millipore,默克密理博,14-497M,PKC η Protein, active, 250 µg

    产品名称：PKC η Protein, active, 250 µg
    产品型号：14-497M
    Active, N-terminal His6-tagged, recombinant amino acids 2-end, of human PKC eta. For use in Kinase Assays.

    merck millipore,默克密理博,14-497M,PKC η Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-497M,PKC η Protein, active, 250 µg

    描述
    产品目录编号 14-497M
    品牌系列 Upstate
    商名
    • Upstate
    描述 PKC η Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant amino acids 2-end, of human PKC eta.

    PKC Lipid activator (Catalog # 20-133) is required for use.
    应用
    应用 Active, N-terminal His6-tagged, recombinant amino acids 2-end, of human PKC eta. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human PKC eta expressed in Sf21 cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006255.3
    Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
    基因符号
    • PKC-L
    • PRKCH
    • PRKCL
    • PKCL
    • MGC26269
    • nPKC-eta
    • MGC5363
    蛋白靶 PKCη
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • P24723
    UniProt汇总 FUNCTION: SwissProt: P24723 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
    SIZE: 682 amino acids; 77563 Da
    TISSUE SPECIFICITY: Most abundant in lung, less in heart and skin.
    DOMAIN: SwissProt: P24723 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
    DISEASE: SwissProt: P24723 # Defects in PRKCH may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of PKC Substrate Peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-497) and in bulk (cat# 14-497-K).

    merck millipore,默克密理博,14-497M,PKC η Protein, active, 250 µg

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