merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3301,Anti-TIMP-1 Antibody, clone 147-6D11

  • merck millipore,默克密理博,MAB3301,Anti-TIMP-1 Antibody, clone 147-6D11

    产品名称：Anti-TIMP-1 Antibody, clone 147-6D11
    产品型号：MAB3301
    This Anti-TIMP-1 Antibody, clone 147-6D11 is validated for use in ELISA, WB, IH(P) for the detection of TIMP-1.

    merck millipore,默克密理博,MAB3301,Anti-TIMP-1 Antibody, clone 147-6D11

  • 产品介绍
  • merck millipore,默克密理博,MAB3301,Anti-TIMP-1 Antibody, clone 147-6D11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Human OnlyWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3301
    Replaces MAB1338
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-TIMP-1 Antibody, clone 147-6D11
    Alternate Names
    • Tissue Inhibitor of Metalloproteinase-1
    产品信息
    格式 Purified
    演示 Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
    应用
    应用 This Anti-TIMP-1 Antibody, clone 147-6D11 is validated for use in ELISA, WB, IH(P) for the detection of TIMP-1.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Immunoblotting: Suggested Dilution 1μg/mL

    Immunohistochemistry on paraffin-embedded tissue sections using PLP fixation; not tested on traditional formalin fixed tissues. Antigen retrieval is HIER methods

    ElA
    生物信息
    免疫原品种 Mouse Mac-1
    克隆 147-6D11
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody specifically reacts with human TIMP-1. This is a purified mouse monoclonal antibody to recombinant human tissue inhibitor of metalloproteinases-1 (recombinant TIMP-1).

    SPECIES REACTIVITY:

    Does not cross-react with mouse and rat TIMP-1.
    同种型 IgG1κ
    品种反应性 Human Only
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003254.2
    Entrez基因汇总 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
    基因符号
    • HCI
    • TIMP1
    • TIMP
    • FLJ90373
    • CLGI
    • EPA
    • EPO
    • TIMP-1
    UniProt编号
    • P01033
    UniProt汇总 FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
    SIZE: 207 amino acids; 23171 Da
    SUBCELLULAR LOCATION: Secreted.
    PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
    SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3301,Anti-TIMP-1 Antibody, clone 147-6D11

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