merck millipore,默克密理愽
  • merck millipore,默克密理博,05-611,Anti-phospho-VASP (Ser239) Antibody, clone 16C2

  • merck millipore,默克密理博,05-611,Anti-phospho-VASP (Ser239) Antibody, clone 16C2

    产品名称：Anti-phospho-VASP (Ser239) Antibody, clone 16C2
    产品型号：05-611
    This Anti-phospho-VASP (Ser239) Antibody, clone 16C2 is validated for use in FC, WB, IC for the detection of phospho-VASP (Ser239).

    merck millipore,默克密理博,05-611,Anti-phospho-VASP (Ser239) Antibody, clone 16C2

  • 产品介绍
  • merck millipore,默克密理博,05-611,Anti-phospho-VASP (Ser239) Antibody, clone 16C2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, FC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-611
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-VASP (Ser239) Antibody, clone 16C2
    产品信息
    格式 Purified
    演示 100µg of mouse IgG1 from serum-free cell culture supernatant, purified by thiophilic adsorption and size exclusion chromatography. Lyophilized from 1ml of PBS, 0.1% sodium azide, PEG and sucrose. Lyophilized powder. Reconstitute with 100 µL H2O (15 min, RT) for a final concentration of 1 mg/mL. Store at -20°C.
    应用
    应用 This Anti-phospho-VASP (Ser239) Antibody, clone 16C2 is validated for use in FC, WB, IC for the detection of phospho-VASP (Ser239).
    主要应用
    • Immunocytochemistry
    • Flow Cytometry
    • Western Blotting
    生物信息
    免疫原品种 phospho-peptide corresponding to amino acids 236-242 of human phospho-VASP (RKV[pS]KQE)
    克隆 16C2
    宿主 Mouse
    特异性 phosphorylated VASP
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Based on sequence homology this antibody is also predicted to cross-react with dog and cow.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003370
    Entrez基因汇总 Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
    基因符号
    • VASP
    修改
    • Phosphorylation
    纯化方法 Thiophilic adsorption chromatography
    UniProt编号
    • P50552
    UniProt汇总 FUNCTION: SwissProt: P50552 # Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. VASP promotes actin nucleation and increases the rate of actin polymerization in the presence of capping protein. Plays a role in actin-based activity of Listeria monocytogenes in platelets (By similarity).
    SIZE: 380 amino acids; 39830 Da
    SUBUNIT: Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions.
    TISSUE SPECIFICITY: Highly expressed in platelets.
    DOMAIN: "SwissProt: P50552 The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
    PTM: Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser-157, the preferred site for PKG, Ser-239. In ADP-activated platelets, phosphorylation by PKA or PKG on Ser-157 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-278 requires prior phosphorylation on Ser-157 and Ser-239. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1.
    SIMILARITY: Belongs to the Ena/VASP family. & Contains 1 WH1 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from CTLL cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-611,Anti-phospho-VASP (Ser239) Antibody, clone 16C2

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