merck millipore,默克密理博,07-1238,Anti-phospho-MARCKS (Ser152/156) Antibody

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merck millipore,默克密理博,07-1238,Anti-phospho-MARCKS (Ser152/156) Antibody
产品名称：Anti-phospho-MARCKS (Ser152/156) Antibody
产品型号：07-1238
This Anti-phospho-MARCKS (Ser152/156) Antibody is validated for use in WB, IH(P) for the detection of phospho-MARCKS (Ser152/156).

merck millipore,默克密理博,07-1238,Anti-phospho-MARCKS (Ser152/156) Antibody

产品介绍

merck millipore,默克密理博,07-1238,Anti-phospho-MARCKS (Ser152/156) Antibody

Replacement Information
Replacement Information	07-1238 is a recommended replacement for AB5879

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, R, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-1238
Replaces	AB5879
描述	Anti-phospho-MARCKS (Ser152/156) Antibody
Alternate Names	Protein kinase C substrate, 80 kDa protein, light chain Myristoylated alanine-rich C-kinase substrate Protein kinase C substrate 80 kDa protein
背景信息	Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) is a widely expressed substrate of PKC. MARCKS is essential in neuronal development, as mice deficient in it die shortly after birth. Through its basic effector region, MARCKS associates with acidic membrane phospholipids, actin filaments, and calmodulin. Poly (ADP-ribose) also binds the basic effector region, blocking calmodulin binding, membrane association, and phosphorylation by PKC, suggesting that MARCKS may be an effector of the DNA-damage signal transduced by poly (ADP-ribose).

产品信息
格式	Affinity Purified
控制	A431 Cell Lysate
演示	Purified rabbit polyclonal IgG in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.

应用
应用	This Anti-phospho-MARCKS (Ser152/156) Antibody is validated for use in WB, IH(P) for the detection of phospho-MARCKS (Ser152/156).
主要应用	Western Blotting
应用说明	Immunohistochemistry(paraffin): Representative images from a previous lot. Optimal Staining of MARCKS With Citrate pH 6.0 Epitope Retrieval: Rat Placenta Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Synthetic peptide corresponding to amino acids surrounding the phosphoSer152/156 of rat MARCKS.
表位	phosphoSer 152/156
宿主	Rabbit
特异性	MARCKS, phosphoSer152/156.
同种型	IgG
品种反应性	MouseRatHuman
Species Reactivity Note	Human, mouse and rat.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_002356.5
Entrez基因汇总	The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
基因符号	FLJ90045 MARCKS MACS 80K-L PRKCSL FLJ14368 phosphomyristin MRACKS PKCSL
修改	Phosphorylation
纯化方法	Affinity Purfied
UniProt编号	P29966
UniProt汇总	FUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. SIZE: 332 amino acids; 31555 Da PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family.

产品使用声明
质量保证	Routinely evaluated by Western Blot on EGF treated A431 lysates. Western Blot Analysis: 1:500 dilution of this lot detected phosphorylated MARCKS on 10 μg of EGF treated A431 lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.