merck millipore,默克密理愽
  • merck millipore,默克密理博,176908,Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem

  • merck millipore,默克密理博,176908,Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem

    产品名称：Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem
    产品型号：176908
    Recombinant, Bacillus anthracis anthrax protective antigen (nicked) expressed in a specialized strain of B.

    merck millipore,默克密理博,176908,Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,176908,Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem

    重要规格表
    描述
    概述 Recombinant, Bacillus anthracis anthrax protective antigen (nicked) expressed in a specialized strain of B. anthracis. PA63 is the carboxyl-terminal 63-kDa fragment obtained by the proteolytic cleavage of the receptor-bound protective antigen (PA), one of the three proteins that comprise anthrax toxin. Unlike native PA, PA63 oligomerizes to form a ring-shaped heptamer that binds up to three copies of EF and/or LF competitively and with high affinity (Kd ~1 nM). Whereas native PA persists on the cell surface, the heptamer is endocytosed, presumably because oligomerization aggregates anthrax toxin receptor. The endocytosed toxic complexes are trafficked to endosomal compartments where the low pH causes the PA63 heptamer to insert into the membrane and form a water-filled channel.
    产品目录编号 176908
    品牌系列 Calbiochem®
    同义词 PA 63
    参考
    参考 Mogridge, J., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 7045.
    Nassi, S., et al. 2002. Biochemistry 41, 1445.
    Singh, Y., et al. 1999. Infect. Immun. 67, 1853.
    Leppla, S.H. 1988. Methods Enzymol. 165, 103.
    产品信息
    具有ATP竞争性 N
    形式 Lyophilized
    配方 Lyophilized from 100 mM NaCL, 10 mM BIS-Tris propane, 1.25% trehalose, pH 8.5.
    Molar Mass 63000
    可逆 N
    生物信息
    主靶 EF and/or LF
    纯度 Single major band at 63 kD by SDS-PAGE
    理化信息
    细胞可渗透 N
    溶解度 H₂O or 50% glycerol
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C or- 70°C) for long term storage or refrigerate (4°C) for short-term (few hours) storage. Avoid rapid freeze-thaw cycles of solutions. Stock solutions are stable for up to 3 months at -20°C or -70°C.
    加拿大出口规定 Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.

    merck millipore,默克密理博,176908,Anthrax Protective Antigen, Bacillus anthracis, Nicked, Recombinant, B. anthracis - Calbiochem

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